http://pypi.python.org/pypi/appdirs is a Python module that offers a cross-platform user_cache_dir function.

So how can a program regenerate files upon rebooting without me knowing?

Oh, there are loads of ways a program can get itself run on startup, and equally loads of ways to hide from you.

You can try running HijackThis to find many more startup hooks that just the Software-MS-Win-CurVer-Run key, and a rootkit finder such as BlackLight to see if there are any more hidden files you can't see. But a persistent self-recreator is often very difficult to remove from inside the OS itself.

Michael is right: the only safe course of action is nuke and pave (reformat and reinstall the OS). Don't rely on your anti-virus to keep you clean, because today's anti-virus tools are almost totally useless against the ever-growing-and-mutating range of web-sploit-installed threats.

I can't comment yet, so i'm posting this as an answer:

This looks like a Trojan which is running in memory. Please, include your TaskManager process list from all users (or preferably with Process Explorer) and try to find a process running from a weird place (like C:\Users\YourUser\AppData\Local\Temp\ ). Kill the process and delete the file. You can try to catch it by monitoring your running tasks for disk writes with both programs.

Also use Autoruns to find which programs are automatically executed when you turn on your machine. Disable those which are completely rare (just be careful not to disable a useful program).

Also you can try to log on "Safe mode" and run Disk Cleanup (sometimes trojans are stored on temp folders). You can manually clean temp folders too (C:\Users\YourUser\AppData\Local\Temp\ and C:\Windows\Temp\ )

If all previous fails, uninstall and reinstall Chrome. Hopefully that will delete the autorun tasks Chrome might have.

After all, if your problem persists, try using another web browser (like Firefox or Opera). Sometimes trojans can setup autorun tasks based on a specific browser.

Also try to include the name of the trojan/virus your antivirus is detecting.

Sometimes it's an art to catch those pests and delete em.