Statins are commonly used to lower cholesterol levels, but they can also help to reduce ceramides in the body. Statins work by inhibiting an enzyme called HMG-CoA reductase, which is involved in the production of both cholesterol and ceramides. Another class of medications that can help to reduce ceramides is fibrates.
In this issue of Cell Metabolism, Xia et al. (Xia et al., 2015) identify a new therapeutic strategy for lowering ceramides and improving metabolic health—driving ceramide degradation. The study focuses…
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More recently, whole-body deletion of Cers1 (and the resulting reduction in C18:0 ceramide concentrations in skeletal muscle) was shown to improve systemic glucose homeostasis and protect mice from high-fat diet–induced…
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The unique combination of 3 essential ceramidesin CeraVe (ceramides 1, 3, 6-II) help replenish skin’s existingceramides, relieving dry skin, by reducing moisture loss, increasing hydration and protecting the…
The accumulation of ceramides can increase in tissues due to excessive supply of either saturated or unsaturated fatty acids, most likely as a result of sphingolipid recycling or the salvage pathway activity.
The study, published in Cell Metabolism online, revealed that the accumulation of ceramides may increase people’s chances of having type 2 diabetes. This occurs when a build-up of ceramides prevents the normal function of adipose (fat) tissue.
Concentrations of ceramide lipids in blood plasma and tissues are strongly associated with the risk of developing type 2 diabetes (T2D), hepatic steatosis, and cardiovascular disease, which are caused by lipotoxicity and insulin resistance (1, 2).
Apart from using ceramide products, you can also look into improving ceramide production naturally by eating right. Wheat ,soy, eggs and dairy contain large amounts of sphingolipids, which can boost ceramide production in your body.
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Avoiding body weight gain, or consuming diets low in saturated fatty acids or fructose from nonfruit sources are a likely means to increase hepatic fatty acid oxidation, inhibit ceramide synthesis,…
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However, several reports have found that ceramide concentrations are significantly decreased by caloric restriction, gastric bypass, aerobic exercise and statin therapy. A significant decrease in plasma ceramides was observed among…
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adipocytes lowers ceramides across many tissues involved in maintaining metabolic homeostasis. Adiponectin is a circulating adipokine that signals through its cognate receptors to enhance insulin sensitivity by reducing intracellular ceramides…
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Reducingceramidesinthebody is an important part of managing and preventing diabetes. By making lifestyle changes, taking medications as prescribed, and considering alternative therapies, it is possible to…
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51K views 9 years ago. Fats called ceramides build up in cells, damage mitochondria and lead to obesity and diabetes, says a BYU researcher. By inhibiting ceramide, Benjamin Bikman reports…
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Our study suggests that HF diets reduce ceramide and lipid synthesis inthe skin by reducing levels of SPT and HMG-CoA reductase through lowered adiponectin and PPAR-α activity. Additionally, they…
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Experiments in mice show that the decrease of Cer16:0 concentration can prevent obesity induced by high-fat diet, improve insulin resistance, and balance thebody's glucose homeostasis; 35 Cer18:0 ...
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