uptodate.com › contents › anticholinergic-poisoning

(See "General approach to drug poisoning in adults".) A summary table to facilitate emergency management of anticholinergic overdose is provided . ANTICHOLINERGIC MEDICATIONS AND POISONS. Over 600 compounds have anticholinergic…

emedicine.medscape.com › article › 812644-treatment

The antidote for anticholinergic toxicity is physostigmine salicylate. Physostigmine is the only reversible acetylcholinesterase inhibitor capable of directly antagonizing the CNS manifestations of...

10. ELOK. 2021

emra.org › emresident › article › physostigmine-antimuscarinic-od

Physostigmine has long been recognized as an antidote to reverse antimuscarinic delirium. However, its effectiveness, safety profile, and dosing have been disputed in recent years. But does this medication deserve…

pubmed.ncbi.nlm.nih.gov › 17496766

Summary: In the proper clinical situation such as pure anticholinergic overdose with severe symptoms, physostigmine can be beneficial. The potential for side effects is not insignificant, and the antidote should…

pubmed.ncbi.nlm.nih.gov › 17453877

Abstract. Physostigmine has been proposed as an antidote for gamma hydroxybutyrate (GHB) intoxication, based on associated awakenings in 1) patients anesthetized with GHB and 2) five of six patients administered…

ncbi.nlm.nih.gov › books › NBK534798

Anticholinergic toxicity is common in the emergency department but rarely fatal.[1] According to the 2015 annual American Association of Poison Control Centers (AAPCC) report, there were just under 14,000 exposures…

drugs.com › dosage › physostigmine

Overdose of drugs that cause anticholinergic syndrome: 2 mg, IM or slow IV, at no more than 1 mg/minute. May repeat dose if life threatening signs (e.g. arrhythmia, convulsions, coma)…

pubmed.ncbi.nlm.nih.gov › 24798647

Use of a physostigmine continuous infusion for the treatment of severe and recurrent antimuscarinic toxicity in a mixed drug overdose. Physostigmine administered as a continuous infusion may be a reasonable…

pubmed.ncbi.nlm.nih.gov › 7228447

Abstract. Most poisonings with anticholinergics deal with simple cases without diagnostic or therapeutic difficulties; however, in difficult or unclarified cases a new method for diagnosis and treatment is the antidote…

pubmed.ncbi.nlm.nih.gov › 2746350

Since physostigmine has been reported to reverse the respiratory depression and somnolence due to opiates, the drug was tried for the treatment of baclofen overdose. In three cases, intravenous physostigmine…

drugs.com › drug-class › antidotes

Most antidotes are not 100% effective, and fatalities may still occur even when an antidote has been given. Some examples of antidotes include: Acetylcysteine for acetaminophen poisoning. Activated charcoal for…