bccancer.bc.ca › drug-database-site › Drug Index › Doxorubicin pegylated liposomal

doxorubicin while preserving the anti-tumour efficacy. Liposomal anthracyclines achieve lower cardiotoxicity by changing tissue distribution and by decreasing rate of drug release. Liposomes cannot escape from the vascular space in…

17. SYYSK. 2018

ema.europa.eu › en › caelyx

Doxorubicin has been available since the 1960s. In Caelyx pegylated liposomal, it is enclosed in ‘pegylated liposomes’ (tiny fat particles coated with a substance called polyethylene glycol). This slows down…

en.wikipedia.org › wiki › Doxorubicin

In the EU doxorubicin pegylated liposomal (as Caelyx) is indicated to treat breast cancer, ovarian cancer, and AIDS-related Kaposi's sarcoma. It is indicated to treat multiple myeloma in combination with…

24. TAMMIK. 2022

ema.europa.eu › en › zolsketil-pegylated-liposomal

Doxorubicin, the active substance in Zolsketil pegylated liposomal, is a cytotoxic medicine that belongs to the group ‘anthracyclines’. It interferes with the DNA in cancer cells, preventing them from making…

pubmed.ncbi.nlm.nih.gov › 12739982

Pegylated liposomal doxorubicin ( doxorubicin HCl liposome injection; Doxil or Caelyx) is a liposomal formulation of doxorubicin, reducing uptake by the reticulo-endothelial system due to the attachment of polyethylene glycol polymers…

pubmed.ncbi.nlm.nih.gov › 9667262

Purpose: Kaposi's sarcoma (KS), the most common neoplasm in patients with AIDS, is a significant clinical problem for which current therapies are frequently unsatisfactory. We conducted a randomized phase III…

pubmed.ncbi.nlm.nih.gov › 25445468

Background: The present multicenter phase II trial evaluated the safety and efficacy of pegylated liposomal doxorubicin (PLD) instead of conventional doxorubicin in standard R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine [Oncovin],…

pubmed.ncbi.nlm.nih.gov › 21850390

In the current study, we analyzed the efficacy and toxicity of pegylated liposomal doxorubicin (PLD) as constituent of the cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen replacing conventional doxorubicin in…

frontiersin.org › articles › 10.3389 › fphar

Pegylated liposomal doxorubicin 1.5 mg/sm was aerosolized in PIPAC procedures.Results: Pharmacokinetics analysis of 10 procedures performed with conventional doxorubicin solution at the dose of 1.5 mg/m2 were compared to 15…

pubmed.ncbi.nlm.nih.gov › 15717736

Encapsulation of doxorubicin in polyethylene glycol-coated liposomes (Doxil/Caelyx [PLD]), was developed to enhance the safety and efficacy of conventional doxorubicin. The liposomes alter pharmacologic and pharmacokinetic parameters of conventional doxorubicin…

pubmed.ncbi.nlm.nih.gov › 24018470

Pegylated liposomal doxorubicin (Caelyx(®) [EU], Doxil(®) [USA]) represents an improved formulation of conventional doxorubicin, with reduced cardiotoxicity and an improved pharmacokinetic profile. As shown by evidence from clinical trials, intravenous…

4. JOULUK. 2020

onclive.com › view › pegylated-doxorubicincarboplatin-plus-bevacizumab

The combination regimen of pegylated liposomal doxorubicin (CD-BEV) with bevacizumab (Avastin) was found to significantly improve progression-free survival (PFS) versus carboplatin/gemcitabine (CG ...

pubmed.ncbi.nlm.nih.gov › 29022970

Detection of mPEGs and mPEG2K-Dox was based on high resolution extracted ions of mPEG and the specific compound. The method was successfully applied to a pharmacokinetic study of doxorubicin, mPEG2K…