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Pegaspargase: A Review in Acute Lymphoblastic Leukaemia

Pegaspargase (Oncaspar ®), a pegylated form of native Escherichia coli-derived L- asparaginase (hereafter referred as E. coliL- asparaginase), is indicated in the USA and EU for the treatment of acute lymphoblastic leukaemia…

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Optimizing pegylated asparaginase use: An institutional guideline for ...

journals.sagepub.com › doi › 1078155219838316

An understanding of the pharmacology of L- asparaginase is inherent to gaining perspective on its efficacy and toxicity profile. Asparagine is a non-essential amino acid, critical to protein synthesis and cell…

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Images for pegylierte asparaginase

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Optimizing pegylated asparaginase use: An institutional guideline for ...

pubmed.ncbi.nlm.nih.gov › 30917738

The incorporation of L- asparaginase and pegylated asparaginase into pediatric-inspired regimens has conferred a survival advantage in treatment of adults with acute lymphoblastic leukemia. Use of asparaginase products requires careful prevention,…

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Asparaginase - Wikipedia

en.wikipedia.org › wiki › Asparaginase

Asparaginase is an enzyme that is used as a medication and in food manufacturing. As a medication, L- asparaginase is used to treat acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL).…

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Novel site-specific PEGylated L-asparaginase - PubMed

pubmed.ncbi.nlm.nih.gov › 30753228

L- asparaginase (ASNase) from Escherichia coli is currently used in some countries in its PEGylated form (ONCASPAR, pegaspargase) to treat acute lymphoblastic leukemia (ALL). PEGylation refers to the covalent attachment of…

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Pegylated asparaginase (Oncaspar) in children with ALL: drug ... - PubMed

pubmed.ncbi.nlm.nih.gov › 10971395

Toxicity was low and comparable to the native enzymes but, in contrast to about 30% of hypersensitivity reactions with conventional reinduction therapy, no allergic reaction was seen. Substituting 4 x…

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PEGYLATED L-ASPARAGINASE PEGYLIERTE L-ASPARAGINASE L-ASPARAGINASE ...

data.epo.org › gpi › EP2451486A1

• veronese f.m.: "improvement of pharmacokinetic, immunological and stability properties of asparaginase by conjugation to linear and branched monomethoxy poly(ethylene glycol)", journal of controlled release, vol. 40, no. 1, january…

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Pegaspargase - an overview | ScienceDirect Topics

sciencedirect.com › topics › medicine-and-dentistry › pegaspargase

Asparaginase was one of the first PEGylated enzymes; it catalyzes the hydrolysis of asparagine to aspartic acid and ammonia. The resulting depletion in asparagine is fatal to leukemic lymphoblasts and…

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PEGylated E. coli asparaginase desensitization: an effective and ...

pubmed.ncbi.nlm.nih.gov › 31296092

An international shortage of erwinia asparaginase has limited the therapeutic options for those experiencing pegaspargase hypersensitivity. Here, we report pegaspargase can be safely administered, while maintaining sustained levels of asparaginase…

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Novel site-specific PEGylated L-asparaginase | PLOS ONE

journals.plos.org › plosone › article

Thus, PEGylation has become a well-established technology, increasing the therapeutic potential of biopharmaceutics like the L- asparaginase (ASNase) . L- asparaginase (L- asparagine amidohydrolase) is an enzyme used on chemotherapy schemes to treat…

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Pegaspargase , vermarktet unter dem Markennamen Oncaspar (Les Laboratoires Servier), ist eine PEGylierte Form der natürlich in dem Bakterium Escherichia coli (E. coli) vorkommenden L-Asparaginase. Sie wird als Arzneistoff in der antineoplastischen Kombinationstherapie der akuten lymphatischen Leukämie (ALL) bei Kindern und Jugendlichen sowie bei Erwachsenen eingesetzt.

May treat: · · Chronische Lymphatische Leukämie

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