The registry entry for {0E270DAA-1BE6-48F2-AC49-FD8E73FEA996} is related to Adobe and can be deleted, according to the post How do I remove the 'Creative Cloud Files' folder from my PC?

However, if your case is similar to the one described in this post, and this registry entry will be re-created on the next reboot, you will need to use the same solution of taking ownership and setting all permissions to Deny.

In the future, I suggest using Revo Uninstaller Free to uninstall software and detect all its leftovers.