Summary
TREM-1 is a transmembrane protein that is expressed on the surface of innate immune cells and can amplify inflammatory responses when activated. It is associated with DAP12 for induction of intracellular signals and modulates signaling pathways induced by PRRs such as TLRs and NLRs.
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Additionally, TREM-1 can be modulated by synthetic peptide blockers like LP17, which can inhibit proinflammatory cascades and have therapeutic effects in neurodegenerative diseases.
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These findings suggest that attenuation of TREM-1 could be a promising treatment for various diseases.
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Summary
Triggering receptor expressed on myeloid cells (TREM) serves to modulate the immune response stimulated by pathogen recognition receptors like TLR and cytokine receptors like IL-1R. TREM is expressed on a number of innate immune cells, including macrophages, dendritic cells, monocytes, and neutrophils.
TREM1 Pathway - BioLegend
biolegend.com
Summary
This study examined the role of TREM-1 in neurodegeneration, and found that LP17, a synthetic peptide blocker of TREM-1, significantly inhibited the lipopolysaccharide-induced upregulation of proinflammatory cascades of inducible nitric oxide synthase (iNOS), cyclooxygenase-2, and nuclear factor-kappa B. Additionally, LP17 was able to inhibit 6-hydroxydopamine-induced locomotor deficit and iNOS messenger RNA expression in zebrafish, and had therapeutic effects in 6-hydroxydopamine-induced PD syndrome using a rat model. These data suggest that the attenuation of TREM-1 could ameliorate neuroinflammatory responses in PD and that this approach may be a promising treatment for Parkinson's disease.
Therapeutic Effect of Modulating TREM-1 via Anti ... - Frontiers
frontiersin.org
Summary
Triggering receptor expressed on myeloid cells 1 an immunoglobulin (Ig) superfamily transmembrane protein that, in humans, is encoded by the TREM1 gene. TREM1 is constitutively expressed on the surface of peripheral blood monocytes and neutrophils, and upregulated by toll-like receptor (TLR) ligands; activation of TREM1 amplifies immune responses.
TREM1 - Wikipedia
wikipedia.org
Pathway Description. The triggering receptor expressed on myeloid cells 1 (TREM1) belongs to the Immunoglobulin (Ig) family of cell surface receptors and is selectively expressed on blood neutrophils, monocytes and…
TREM1 Signaling | GeneGlobe
qiagen.com
