Summary
Sacubitril/valsartan is a combination drug used to treat heart failure and approved by the FDA in 2015. It is a combination of an antihypertensive drug and an angiotensin II receptor antagonist, which work together to relax blood vessels and make it easier for the heart to pump blood to the body.
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It has been found to reduce the risk of hospitalization and death from heart failure.
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However, it should not be taken with certain medications, such as ACE inhibitors or ARBs, and should not be taken with any medication that contains aliskiren.
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Sacubitril/valsartan is the first agent to be approved in a new class of drugs called angiotensin receptor neprilysin inhibitor (ARNI). The medication is FDA-approved to treat patients with chronic heart…
Sacubitril/Valsartan - StatPearls - NCBI Bookshelf
nih.gov
Summary
Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug sacubitril/valsartan, known during trials as LCZ696 and marketed under the brand name Entresto, is a treatment for heart failure. It was approved under the FDA's priority review process for use in heart failure on July 7, 2015.
Sacubitril - Wikipedia
wikipedia.org
Summary
This study found that sacubitril/valsartan did not result in a significantly lower rate of total hospitalizations for heart failure and death from cardiovascular causes among patients with heart failure and an ejection fraction of 45% or higher. The combination of sacubitril and an angiotensin II receptor antagonist produced greater vasodilation and natriuresis, and the results suggest that the combination of valsartan and neprilysin inhibition may have beneficial effects on natriuretic peptides and natriuretic peptides in patients with heart failure and preserved ejection fraction. The combination of sacubitril and an angiotensin II receptor antagonist may have beneficial effects on natriuretic peptides and natriuretic peptides in patients with a preserved ejection fraction.
Sacubitril - an overview | ScienceDirect Topics
sciencedirect.com
Summary
Sacubitril and valsartan are blood pressure medicines used to treat chronic heart failure in adults and children. They work by lowering the risk of needing to be hospitalized and lowering the risk of death from heart failure. They should not be taken with certain medications, such as ACE inhibitors or ARBs, and should not be taken with any medication that contains aliskiren.
Sacubitril and valsartan Uses, Side Effects & Warnings - Drugs.com
drugs.com
Summary
Sacubitril belongs to a class of drugs called neprilysin inhibitors and valsartan belongs to a class of drugs called angiotensin receptor blockers (ARBs). They work by relaxing blood vessels so that blood can flow more easily, which makes it easier for your heart to pump blood to your body.
Entresto (sacubitril/valsartan) dosing, indications, interactions ...
medscape.com
