Summary
PEGylation is the process of attaching polyethylene glycol (PEG) polymer chains to molecules and macrostructures, such as drugs, proteins or vesicles, to modify their interactions and slow down their degradation and elimination in vivo.
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PEGylation can also improve the pharmacokinetics of proteins and peptides by increasing their molecular mass and shielding them from proteolytic enzymes.
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PEGylation is achieved by either non-covalent or covalent attachment of PEG to a protein, peptide or antibody, which can alter its physiochemical properties such as conformation, electrostatic binding and hydrophobicity.
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Summary
PEGylation is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol (PEG, in pharmacy called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated. PEGylation affects the resulting derivatives or aggregates interactions, which typically slows down their coalescence and degradation as well as elimination in vivo.
PEGylation - Wikipedia
wikipedia.org
Summary
Pegylation, the process by which polyethylene glycol chains are attached to protein and peptide drugs, can overcome these and other shortcomings. By increasing the molecular mass of proteins and peptides and shielding them from proteolytic enzymes, pegylation improves pharmacokinetics.
Effect of pegylation on pharmaceuticals | Nature Reviews Drug Discovery
nature.com
Summary
PEGylation is defined as the addition of polyethylene glycol to a biological compound to be protected from destruction by the immune system (El-Say and El-Sawy, 2017) and so greatly prolong its biological half-life and targeted delivery such as antibody–drug conjugates (ADCs).
PEGylation - an overview | ScienceDirect Topics
sciencedirect.com
Summary
PEGylation of a protein conjugate is the process by which PEG is either non-covalently or covalently attached to a potential protein, peptide or antibody of interest to produce alterations in the physiochemical properties of the macromolecule in areas like conformation, electrostatic binding and hydrophobicity.
What is PEGylation and why is it an Important Process?
enzolifesciences.com
The term PEGylation describes the modification of biological molecules by covalent conjugation with polyethylene glycol (PEG), a non-toxic, non-immunogenic polymer, and is used as a strategy to overcome disadvantages associated…
The impact of PEGylation on biological therapies - PubMed
nih.gov
