Mural nodules are small nubbins of solid tissue on the inner wall of a cyst.
They are most commonly associated with primary ovarian mucinous neoplasms.
Genetic evidence suggests that mural nodules are clonal to the associated mucinous ovarian tumor.
Morphological, immunohistochemical, and genetic features of mural nodules vary, and can include sarcoma-like, benign neoplastic, or malignant elements.
Treatment typically involves radiation therapy, chemotherapy, and surgery.
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This study investigated the clincopathological and molecular features of three cases with mural nodules in ovarian mucinous tumors. The results showed that the mural nodules were composed of CK+ and CK7+ spindled cells and polygonal cells with marked pleomorphism, and that the K-RAS, PIK3CA, AKT1, and H-RAS gene mutation status in both components of epithelial elements and mural nodules were found in both mucinous tumors and mural nodules. The results suggest that the histogenesis of the mural nodules is still unclear, and that meticulous treatment for these patients is necessary.
Ovarian mucinous tumors with mural nodules: immunohistochemical and ...
This study analyzed the morphological, immunohistochemical, and genetic features of 13 mucinous ovarian tumors and associated mural nodules. Twelve of the 13 cases showed genetic evidence of clonality between the mural nodule(s) and associated mucinous ovarian tumor, including all three tumors with sarcoma-like morphology. No single recurrent genetic alteration was associated with mural nodule development, and no recurrent genetic differences were identified between mural nodules with sarcoma-like, anaplastic carcinomatous, and sarcomatous morphology.
Mural nodules in mucinous ovarian tumors represent a ... - Nature
Mural nodules in mucinous cystic neoplasms are grossly circumscribed nodules that are most associated with primary ovarian mucinous neoplasms. They can be reactive (sarcoma-like), benign neoplastic (leiomyomatous), or malignant, and can present a diagnostic challenge as the discrimination between truly malignant versus reactive mural nodules can be difficult. Treatment typically involves radiation therapy, chemotherapy, and chemotherapy, and the most common treatment is surgery.
Pathology Outlines - Mural nodules in mucinous cystic neoplasms
Mural nodules may be either reactive or neoplastic. Neoplastic mural nodules may be composed of benign elements, carcinoma, carcinoma with reactive elements, sarcoma, or an admixture of carcinoma and sarcoma; the latter category has some similarities to malignant mixed mesodermal tumors.
Mural nodules in common epithelial tumors of the ovary
There is a wide differential diagnosis including ovarian cystic neoplasm with solid component, mature cystic teratoma with hyperechoic Rokitansky nodule , hemorrhagic cyst with clot and endometrioma with clot or debris.…
The Radiology Assistant : Ovarian cystic lesions