lenacapavir

Summary

Lenacapavir is an antiretroviral medication used to treat HIV/AIDS, approved by the U.S. Food and Drug Administration for the treatment of HIV-1 infection in heavily treatment-experienced adults with multi-drug resistant HIV-1 infection. 1 2 3 It works by interfering with capsid-mediated nuclear uptake of preintegration complexes and impairing virion production, inhibiting viral replication at both early and late stages of the life cycle. 4 1

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Summary Lenacapavir is a first-in-class inhibitor of HIV-1 capsid function. 5 By interfering with capsid-mediated nuclear uptake of preintegration complexes and impairing virion production, lenacapavir inhibits viral replication at both early and late stages of the life cycle
Capsid Inhibition with Lenacapavir in Multidrug-Resistant HIV-1 ...
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nejm.org

Summary Lenacapavir , sold under the brand name Sunlenca, is an antiretroviral medication used to treat HIV/AIDS. It is taken by mouth or by subcutaneous injection.
Lenacapavir - Wikipedia
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wikipedia.org

Summary (Nasdaq: GILD) today announced that Sunlenca ® (lenacapavir), in combination with other antiretroviral(s) (ARV), has been granted approval by the U.S. Food and Drug Administration (FDA) for the treatment of HIV-1 infection in heavily treatment-experienced (HTE) adults with multi-drug resistant (MDR) HIV-1 infection
Sunlenca® (lenacapavir) Receives FDA Approval as a First-in-Class ...
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gilead.com

Lenacapavir oral comes as a tablet to take by mouth. It is usually taken with or without food once a day for the first two days before starting lenacapavir injection.…
Lenacapavir Oral: MedlinePlus Drug Information
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medlineplus.gov

Summary Today, the U.S. Food and Drug Administration approved Sunlenca (lenacapavir), a new type of antiretroviral medication for adult patients living with human immunodeficiency virus type 1 (HIV-1), whose HIV infections cannot be successfully treated with other available treatments due to resistance, intolerance, or safety considerations
FDA Approves New HIV Drug for Adults with Limited Treatment Options
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Adults—At first, 600 milligrams (mg) (2 tablets) once a day on Days 1 and 2. Followed by 300 mg (1 tablet) once on Day 8. Then, 927 mg (2 vials)…
Lenacapavir (Oral Route) Proper Use - Mayo Clinic
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mayoclinic.org

Induction: Participants will receive oral lenacapavir 600 mg, 600 mg, and 300 mg at Days 1, 2, and 8, respectively. Participants will also begin oral daily emtricitabine/tenofovir alafenamide (F/TAF) 200/25mg…
Study to Evaluate the Safety and Efficacy of Lenacapavir in Combination ...
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clinicaltrials.gov

Lenacapavir is given alongside two other fully active agents in the treatment of HIV if at least one agent has a high barrier to resistance. If not, then three fully…
Lenacapavir: a new treatment of resistant HIV-1 infections
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thelancet.com