Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease in which the immune system attacks the body's own tissues at the connection between nerve and muscle.
Specifically, the immune system attacks the calcium channels on nerve endings, leading to a loss of some of these channels and resulting in muscle weakness.
In about 50 to 60 percent of cases, LEMS is associated with an underlying disease, particularly small cell lung cancer.
In November 2018, the FDA approved Catalyst Pharmaceuticals Firdapse for the treatment of LEMS.
MDA-supported scientists are working to reveal numerous facets of LEMS, from identifying possible causes and triggers to the disease's molecular underpinnings to specific treatment strategies.
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Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease — a disease in which the immune system attacks the body's own tissues. The attack occurs at the connection between nerve and muscle (the neuromuscular junction) and interferes with the ability of nerve cells to send signals to muscle cells.
Lambert-Eaton Myasthenic Syndrome (LEMS) - Diseases | Muscular ...
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder. In this condition, your body interferes with a chemical needed for nerve cells to “tell” your muscle fibers to contract. Muscle weakness is a common symptom. Many people with LEMS have small-cell lung cancer.
Lambert-Eaton Myasthenic Syndrome (LEMS) - Cleveland Clinic
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LEMS is the second-most common disorder of neuromuscular transmission.2,3 LEMS affects an estimated 3,000 individuals in the US, most of whom are adults4,5 Debilitating muscle weakness and fatigue characterize LEMS6…
Lambert-Eaton myasthenic syndrome (LEMS) - Mayo
Lambert–Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder characterized by muscle weakness of the limbs. Around 60% of those with LEMS have an underlying malignancy, most commonly small-cell lung…
Lambert–Eaton myasthenic syndrome - Wikipedia
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