System extensions can be removed from a Mac by dragging the application that delivered the System Extension to the Trash/Bin and entering an admin password.
Alternatively, the systemextensionsctl tool can be used to uninstall system extensions by providing the team and bundle identifiers of the system extension and running the command with root privileges.
If FileVault is enabled, the kernel file can be removed in recovery mode or manually.
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If you drag the application that delivered the System Extension to the Trash/Bin, a dialog appears, indicating that the System Extension will be deleted. An admin password is also required to complete the removal, but at least Recovery Mode is not required.
How to script the uninstallation of macOS System Extensions
Apple has provided a tool called systemextensionsctl to help Mac admins uninstall system extensions, which can be done by providing the team and bundle identifiers of the system extension and running the command with root privileges. To uninstall a system extension using systemextensionsctl, users must first locate the system extension in question inside the application and run the commands. System Integrity Protection (SIP) must be disabled as of September 1, 2020, but this limitation is expected to be removed by Apple in the near future.
Uninstalling macOS system extensions | Der Flounder
This article provides instructions on how to remove kernel extensions on a Mac, which are usually stored in the Extensions folder in deep subfolders. It explains how to check whether the FileVault option is turned on or not, how to remove the kernel file in the recovery mode, and how to remove it manually if FileVault is enabled. Additionally, it provides tips on how to fix a kernel panic error on Mac.
How to Uninstall Kernel Extensions on a Mac | Nektony