Summary
Depolarization of the cell membrane opens a calcium channel, leading to an influx of Ca2+ ions and the fusion of insulin vesicles to the cell, resulting in insulin secretion.
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Increased intracellular glucose leads to increased production of ATP, and an increase in the ATP/ADP ratio, which closes the potassium channel and depolarizes the cell.
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Summary
The closure of the ATP-sensitive potassium channels causes depolarization of the cell membrane causing the cell membrane to stretch which causes the voltage-gated calcium channel on the membrane to open causing an influx of Ca2+ ions. This influx then stimulates fusion of the insulin vesicles to the cell
Insulin signal transduction pathway - Wikipedia
wikipedia.org
High blood sugar stimulates clusters of special cells, called beta cells, in your pancreas to release insulin . The more glucose you have in your blood, the more insulin your pancreas…
How Secreted Insulin Works in Your Body - WebMD
webmd.com
The presence of a positive feedback mechanism for insulin secretion mediated by the insulin receptor provides a potential link between impaired insulin secretion and insulin resistance. MATERIALS AND METHODS Chemicals…
Insulin Release From Beta Cells | DiabetesTalk.Net
diabetestalk.net
They respond positively, in terms of insulin secretion, not only to changes in the extracellular glucose concentration, but also to activators of the phospholipase C (cholecystokinin or acetylcholine), and to…
[Insulin secretion: mechanisms of regulation] - PubMed
nih.gov
The initial steps of glucose-stimulated insulin release are depicted in Fig. 21.7 and discussed in detail in Chapters 7 and 10 in connection with mutations in the sulfonylurea receptor (SUR)-Kir6…
Insulin Release - an overview | ScienceDirect Topics
sciencedirect.com
