how does depolarization release insulin


Depolarization of the cell membrane opens a calcium channel, leading to an influx of Ca2+ ions and the fusion of insulin vesicles to the cell, resulting in insulin secretion. 1 2 3 Increased intracellular glucose leads to increased production of ATP, and an increase in the ATP/ADP ratio, which closes the potassium channel and depolarizes the cell. 1

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Summary The closure of the ATP-sensitive potassium channels causes depolarization of the cell membrane causing the cell membrane to stretch which causes the voltage-gated calcium channel on the membrane to open causing an influx of Ca2+ ions. This influx then stimulates fusion of the insulin vesicles to the cell
Insulin signal transduction pathway - Wikipedia

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They respond positively, in terms of insulin secretion, not only to changes in the extracellular glucose concentration, but also to activators of the phospholipase C (cholecystokinin or acetylcholine), and to…
[Insulin secretion: mechanisms of regulation] - PubMed

Introduction Nursing Pharmacology Videos Regulation of Insulin Release and Insulin Action PhysioPathoPharmaco 99.8K subscribers Subscribe 112K views 5 years ago Discusses the mechanism that...
Regulation of Insulin Release and Insulin Action - YouTube

Inhibition of K ATP channels by glucose or sulfonylureas causes depolarization of the β-cell membrane; in turn, this triggers the opening of voltage-gated Ca 2+ channels, eliciting Ca 2+ influx…
Sulfonylurea Stimulation of Insulin Secretion - Diabetes

The initial steps of glucose-stimulated insulin release are depicted in Fig. 21.7 and discussed in detail in Chapters 7 and 10 in connection with mutations in the sulfonylurea receptor (SUR)-Kir6…
Insulin Release - an overview | ScienceDirect Topics

Mechanism of how insulin is released from pancreatic Beta cells - YouTube 0:00 / 6:38 Mechanism of how insulin is released from pancreatic Beta cells 59,781 views Sep 29, 2016…
Mechanism of how insulin is released from pancreatic Beta cells