amlodipine half life


Amlodipine has an elimination half life of 30 to 50 hours 1 , which means it takes about 5.5 elimination half lives for a medicine to be out of your system. 1 It is taken by mouth 2 and is a low-clearance, dihydropyridine calcium antagonist. 3 Side effects, dosage, and other considerations should be taken into account before taking amlodipine. 4

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Summary Amlodipine is a low-clearance, dihydropyridine calcium antagonist. The slow rate of elimination (elimination half-life of 40-60 h) confers several pharmacokinetic characteristics that are not seen with other calcium-antagonist drugs.
Pharmacokinetics and pharmacodynamics of amlodipine

Amlodipine has an elimination half life of 30 to 50 hours. This is the time it takes for your body to reduce the plasma levels by half. It takes about…
How long does amlodipine stay in your system? -

Amlodipine has been studied in healthy volunteers following oral administration of 14 C-labelled drug. Amlodipine is well absorbed by the oral route with a mean oral bioavailability around 60%; the…
Amlodipine - Wikipedia

Compared to nifedipine and other medications in the dihydropyridine class, amlodipine has the longest half-life at 30 to 50 hours. The benefit of such a long half-life is the ability…
Amlodipine - StatPearls - NCBI Bookshelf

Mean effective half-life:30 to 50 hours. Time to steady-state:between 4 and 10 days after starting therapy. Mean accumulation ratio: 3.70. Terminal phase half-life: 55.9 hours. Amlodipine has an oral bioavailability…
Amlodipine Half-Life – How Long Does it Stay in Your System?

Amlodipine may be used for the treatment of hypertension or ischemic heart disease in patients with HFrEF, but has no effect on functional status or mortality (ACCF/AHA [Yancy 2013]). Hepatic…
AmLODIPine: Dosage, Mechanism/Onset of Action, Half-Life -

The half - life of amlodipine is about 30-50 hours, meaning that “steady state” occurs between 4 and 10 days after starting therapy. As you can see in the table above, peak…
Using Amlodipine Responsibly in Hospitalized Patients