2d6 slow metabolizer pain medication

People with slow metabolizers of CYP2D6 and CYP2C19 may experience difficulty in managing pain with commonly prescribed opiate medications such as codeine, tramadol, hydrocodone, and oxycodone. 1 Additionally, they may also have difficulty in managing pain with diazepam, carisoprodol, clopidogrel, proton pump inhibitors, and several antidepressants including amitriptyline, clomipramine, doxepin, imipramine, and trimipramine. 1 CYP2D6 enzymes also break down other medicines such as ondansetron and beta blockers. 2