People with slow metabolizers of CYP2D6 and CYP2C19 may experience difficulty in managing pain with commonly prescribed opiate medications such as codeine, tramadol, hydrocodone, and oxycodone.
Additionally, they may also have difficulty in managing pain with diazepam, carisoprodol, clopidogrel, proton pump inhibitors, and several antidepressants including amitriptyline, clomipramine, doxepin, imipramine, and trimipramine.
CYP2D6 enzymes also break down other medicines such as ondansetron and beta blockers.
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Cytochrome P450 2D6, known as CYP2D6, enzymes break down several commonly used medicines. These include codeine, tramadol, and some other pain relievers; ondansetron ; some medicines to treat depression or other mental health disorder; and beta blockers (used for heart conditions and high blood pressure).
Cytochrome P450 2D6 (CYP2D6) and Medicines - Together by St. Jude™
For instance, CYP-2D6 is completely responsible for some drugs’ metabolism. It appears completely re-sponsible for the metabolism of the antihypertensive/B-blocker, metoprolol (Lopressor®/Toprol®), while the antihypertensive/B blocker, propranolol (In-deral®) is metabolized…
Non-responsive Pain Patients with CYP-2D6 Defect
Codeine is metabolized by CYP2D6 to its active metabolite, morphine. Clinical studies have shown that CYP2D6 poor metabolizers have poor analgesic response as a result of the reduced...
Genetic Factors in Drug Metabolism | AAFP
The second class includes antiarrhythmic medications such as flecainide, lidocaine, mexiletine, propafenone, and quinidine. Lastly, the other remaining medication substrates that are worth mentioning include cinacalcet, dextromethorphan, dolasetron, ondansetron, ritonavir,…
What Medications are Likely to be Influenced by the Genetic ...
Medications : The CYP2D6 enzyme metabolizes (breaks down) about 25% of pharmaceutical drugs , including SSRIs, opioids, tamoxifen, dextromethorphan, and beta-blockers. Which drugs are metabolized by CYP2D6 ? Here is a partial list…
CYP2D6 gene and medication reactions - Genetic Lifehacks